Attenuation of Acute Lung Inflammation and Injury by Whole Body Cooling in a Rat Heatstroke Model
Figure 5
Values of acute lung injury histologic score (top panel) as well as illustrative lung microscopic picture (bottom panel) for normothermic rats (A; ), untreated heat stressed rats (B; ), and heat stressed rats treated with whole body cooling for 20 minute (C; ). The untreated heat stressed rat displayed advanced alveolar collapse, thicken interstitium in perivascular space, and severe inflammatory cells infiltration in alveolar space and interstitium. The lung pathologic changes that occurred during heat stress were greatly attenuated by whole body cooling. X 400.
