BioMed Research International / 2009 / Article / Fig 2

Research Article

Hypercholesterolaemic Serum Increases the Permeability of Endothelial Cells through Zonula Occludens-1 with Phosphatidylinositol 3-Kinase Signaling Pathway

Figure 2

Hypercholesterolemic serum could alter the distribution of ZO-1 in endothelial cells, which seemed to be dose dependent. PI3K specific inhibitor wortmannin could significantly reverse the effect induced by hypercholesterolemic serum. (a) serum free medium; (b) normal rabbit serum; (c) low concentration of hypercholesterolemic serum (0.04 mMol/L); (d) high concentration of hypercholesterolemic serum (0.32 mMol/L); (e) c plus 100 nMol/L wortmannin; (f) d plus 100 nMol/L wortmannin.
814979.fig.002a
(a)
814979.fig.002b
(b)
814979.fig.002c
(c)
814979.fig.002d
(d)
814979.fig.002e
(e)
814979.fig.002f
(f)

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.