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Journal of Biomedicine and Biotechnology
Volume 2009, Article ID 841468, 5 pages
Research Article

Relationship between Estradiol and Antioxidant Enzymes Activity of Ischemic Stroke

1Department of Biochemistry & Nutrition, School of Medicine, Hamadan University of Medical Sciences, 65178/518 Hamadan, Iran
2Department of Neurology, Hamadan University of Medical Sciences, 65178/518 Hamadan, Iran
3Department of Clinical Biochemistry, Faculty of Medicine, Kermanshah University of Medical Science, 6714869914 Kermanshah, Iran
4Department of Biochemistry, Faculty of Medicine, Zahedan University of Medical Science, 4318198167 Zahedan, Iran

Received 26 March 2009; Revised 5 July 2009; Accepted 24 July 2009

Academic Editor: Xudong Huang

Copyright © 2009 Nasrin Sheikh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some evidence suggests the neuroprotection of estrogen provided by the antioxidant activity of this compound. The main objective of this study was to determine the level of estradiol and its correlation with the activity of antioxidant enzymes, total antioxidant status and ferritin from ischemic stroke subjects. The study population consisted of 30 patients with acute ischemic stroke and 30 controls. There was no significant difference between estradiol in stroke and control group. The activity of superoxide dismutase and level of ferritin was higher in stroke compared with control group ( , , resp.). There was no significant correlation between estradiol and glutathione peroxidase, glutathione reductase, catalase, total antioxidant status, and ferritin in stroke and control groups. We observed inverse correlation between estradiol with superoxide dismutase in males of stroke patients ( , ). Our results supported that endogenous estradiol of elderly men and women of stroke or control group has no antioxidant activity.