Bioinformatics Methods for Learning Radiation-Induced Lung Inflammation from Heterogeneous Retrospective and Prospective Data

Figure 4

A schematic diagram of the possible cellular and molecular events involved in pulmonary injury by radiation. Cellular interaction among endothelial cells, alveolar epithelial cells, macrophages, lymphocytes, and fibroblasts, through cytokine mediators of chemokines, selectins, inflammatory cytokines, and fibrotic cytokines are involved (from Chen et al., Seminars in Surgical Oncology, 2003).