Cytotoxic Effect of Recombinant Mycobacterium tuberculosis CFP-10/ESAT-6 Protein on the Crucial Pathways of WI-38 Cells

Table 1

The values of the descriptors constituting the composite score, R_r, and the selected pathways sorted in the ascending order of R_r derived by the pathway topology analysis.

Pathway		Density			Average significance		MD-Cluster		MUD-Cluster		Composite score
Entry	Name	𝐾	𝑄𝑑	𝑄𝑝𝑑	𝑄𝑠	𝑄𝑝𝑠	𝑁𝑐𝑑	𝑄𝑐𝑑	𝑁𝑐𝑢	𝑄𝑐𝑢	𝑅𝑟
hsa04510	Focal adhesion	65	0.3351	0.2697	0.00130	0.00000039	11	0.00177	13	0.00200	46
hsa00450	Selenoamino acid metabolism	14	0.4118	0.5833	0.00119	0.00000365	6	0.00195	7	0.00221	49
hsa00230	Purine metabolism	54	0.3506	0.4230	0.00501	0.00002726	44	0.00566	51	0.00523	59
hsa00271	Methionine metabolism	11	0.6875	0.3158	0.00239	0.00001452	4	0.00044	7	0.00239	59.5
hsa00260	Glycine, serine and threonine metabolism	16	0.3556	0.1391	0.00168	0.00000594	6	0.00153	8	0.00082	61.5
hsa00330	Arginine and proline metabolism	21	0.3448	0.2075	0.00207	0.00001056	10	0.00223	14	0.00388	64
hsa04512	ECM-receptor interaction	31	0.3563	0.0909	0.00076	0.00000023	2	0.00010	5	0.00058	71.5
hsa00280	Valine, leucine and isoleucine degradation	19	0.3519	0.3913	0.00636	0.00002807	10	0.00657	14	0.00760	72
hsa00310	Lysine degradation	18	0.3462	0.4231	0.00453	0.00000841	5	0.01567	5	0.00035	82
hsa00100	Biosynthesis of steroids	8	0.4444	0.3902	0.00754	0.00006827	9	0.00769	9	0.00769	87
hsa04670	Leukocyte transendothelial migration	31	0.2650	0.0656	0.00135	0.00000028	2	0.00007	3	0.00030	87.5
hsa04910	Insulin signaling pathway	41	0.3037	0.1647	0.00713	0.00001028	8	0.00535	9	0.00583	89.5
hsa00380	Tryptophan metabolism	30	0.3488	0.2289	0.00850	0.00006979	6	0.00455	7	0.00543	100
hsa00130	Ubiquinone biosynthesis	7	0.4667	0.2500	0.00672	0.00003048	2	0.00552	2	0.00552	100
hsa00564	Glycerophospholipid metabolism	19	0.2468	0.2464	0.00692	0.00005076	7	0.00742	10	0.00786	103.5
hsa00020	Citrate cycle (TCA cycle)	14	0.4643	0.1121	0.00959	0.00006191	7	0.00758	7	0.00758	105
hsa00650	Butanoate metabolism	20	0.4545	0.2326	0.00713	0.00007358	6	0.00977	6	0.00977	108
hsa04514	Cell adhesion molecules (CAMs)	36	0.2727	0.1565	0.00305	0.00009319	2	0.00195	2	0.00195	112
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13	0.2826	0.1200	0.00513	0.00012724	3	0.00875	3	0.00875	135.5
hsa00500	Starch and sucrose metabolism	23	0.2949	0.1250	0.00955	0.00018004	5	0.01366	6	0.01538	141.5
hsa00625	Tetrachloroethene degradation	4	0.4444	0.1250	0.02087	0.00043538	2	0.02087	2	0.02087	149
hsa00970	Aminoacyl-tRNA biosynthesis	12	0.3750	0.0476	0.00654	0.00077841	2	0.02790	2	0.02790	154
hsa00040	Pentose and glucuronate interconversions	6	0.2500	0.0588	0.00915	0.00050551	2	0.02248	2	0.02248	171