Cytotoxic Effect of Recombinant Mycobacterium tuberculosis CFP-10/ESAT-6 Protein on the Crucial Pathways of WI-38 Cells

Table 2

Gene names, gene descriptions, and significance analysis results of mapped genes in focal adhesion pathway obtained via SAM analysis, where “[]’’ showed upregulated (+) or downregulated (−) by rCFES treatment at q-value <5%.

No.	Gene	Gene Description	𝑞-value
1	SHC3	SHC transforming protein 3	0.0000 [+]
2	ACTN2	Actinin, alpha 2	0.0068 [+]
3	BIRC3	Baculoviral IAP repeat-containing 3	0.0211 [+]
4	SPP1	Secreted phosphoprotein 1	0.0211 [+]
5	AF086032	Protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.0278 [+]
6	KDR	Kinase insert domain receptor	0.0278 [+]
7	DDI1	DDI1, DNA-damage inducible 1,homolog 1 (S. cerevisiae)	0.0278 [+]
8	ACTB	Actin, beta	0.0000 [−]
9	FLNA	Filamin A, alpha(actin binding protein 280)	0.0000 [−]
10	ACTG1	Actin, gamma 1	0.0000 [−]
11	CAV1	Caveolin 1, caveolae protein, 22kDa	0.0000 [−]
12	ITGB1	Integrin, beta 1	0.0000 [−]
13	ITGA6	Integrin, alpha 6	0.0000 [−]
14	COL1A2	Collagen, type I, alpha 2	0.0000 [−]
15	CAPN2	Calpain 2, (m/II) large subunit	0.0000 [−]
16	AKT1	V-akt murine thymoma viral oncogene homolog 1	0.0010 [−]
17	TNXB	Tenascin XB	0.0010 [−]
18	ITGA5	Integrin, alpha 5(fibronectin receptor, alpha polypeptide)	0.0010 [−]
19	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.0014 [−]
20	ITGA8	Integrin, alpha 8	0.0014 [−]
21	ITGA4	Integrin, alpha 4	0.0014 [−]
22	PIK3R3	Phosphoinositide-3-kinase,regulatory subunit 3 (p55, gamma)	0.0014 [−]
23	FN1	Fibronectin 1	0.0014 [−]
24	LAMA4	Laminin, alpha 4	0.0016 [−]
25	THBS1	Thrombospondin 1	0.0016 [−]
26	IGF1R	Insulin-like growth factor 1 receptor	0.0016 [−]
27	COL1A1	Collagen, type I, alpha 1	0.0016 [−]
28	CCND1	Cyclin D1	0.0016 [−]
29	MET	Met proto-oncogene(hepatocyte growth factor receptor)	0.0016 [−]
30	ACTN4	Actinin, alpha 4	0.0019 [−]
31	AK025363	Parvin, alpha	0.0019 [−]
32	AKT2	V-akt murine thymoma viral oncogene homolog 2	0.0019 [−]
33	CAV2	Caveolin 2	0.0027 [−]
34	VCL	Vinculin	0.0027 [−]
35	ZYX	Zyxin	0.0027 [−]
36	TNC	Tenascin C (hexabrachion)	0.0027 [−]
37	ACTN3	Actinin, alpha 3	0.0028 [−]
38	VASP	Vasodilator-stimulated phosphoprotein	0.0028 [−]
39	COL5A1	Collagen, type V, alpha 1	0.0028 [−]
40	VEGFC	Vascular endothelial growth factor C	0.0039 [−]
41	FAK	Focal adhesion kinase	0.0047 [−]
42	PARVB	Parvin, beta	0.0047 [−]
43	COL4A6	Collagen, type IV, alpha 6	0.0047 [−]
44	LAMA5	Laminin, alpha 5	0.0068 [−]
45	MAPK1	Mitogen-activated protein kinase 1	0.0088 [−]
46	AK025363	Parvin, alpha	0.0019 [−]
47	THBS4	Thrombospondin 4	0.0116 [−]
48	ERBB2	V-erb-b2 erythroblastic leukemiaviral oncogene homolog 2	0.0157 [−]
49	AF207599	Homo sapiens pRb-interacting protein RbBP-36 mRNA	0.0157 [−]
50	DOCK1	Dedicator of cytokinesis 1	0.0157 [−]
51	COL5A2	Collagen, type V, alpha 2	0.0211 [−]
52	PIK3R5	Phosphoinositide-3-kinase, regulatory subunit 5, p101	0.0211 [−]
53	ITGAV	Integrin, alpha V	0.0211 [−]
54	LAMA2	Laminin, alpha 2	0.0278 [−]
55	ARHGAP5	Rho GTPase activating protein 5	0.0278 [−]
56	VAV2	Vav 2 oncogene	0.0278 [−]
57	CAV3	Caveolin 3	0.0278 [−]
58	BCAR1	Breast cancer anti-estrogen resistance 1	0.0369 [−]
59	EGFR	Epidermal growth factor receptor	0.0369 [−]
60	MAPK9	Mitogen-activated protein kinase 9	0.0369 [−]
61	AA599881	Platelet-derived growth factor receptor, alpha polypeptide	0.0474 [−]
62	THBS1	Thrombospondin 1	0.0016 [−]
63	GRB2	Growth factor receptor-bound protein 2	0.0474 [−]
64	LAMA3	Laminin, alpha 3	0.0474 [−]
65	CRKL	V-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.0474 [−]