Gene Expression Analysis of an EGFR Indirectly Related Pathway Identified PTEN and MMP9 as Reliable Diagnostic Markers for Human Glial Tumor Specimens

Figure 6

Statistical trends of PTEN (black dotted line) and MMP9 (grey dotted line) expression in control (C), anaplastic astrocytomas (III) and glioblastoma multiforme (IV) specimens (Panel A), and in normal human astrocytes (NHA), glioma PRT-HU2 (HU2), and U138-MG (U138) cells (Panel B). Trends are calculated using average quantitative expression of PTEN and MMP9, and adopting exponential (Espo) models of prediction as follows: PTEN (C, III, IV average expression samples), 𝑦=2148𝑒^−1.29x; MMP9 (C, III, IV), 𝑦=83716𝑒^0.50x; PTEN (NHA, HU2, U138), 𝑦=118596𝑒^−1.82x; MMP9 (NHA, HU2, U138), 𝑦=42439𝑒^1.40x.

(a)

(b)