Quantification of Spatial Parameters in 3D Cellular Constructs Using Graph Theory
Common cell subgraph patterns are distinct from patterns extracted from random graphs. Subgraph patterns were identified that represented local graph topologies and compared to their frequency in random graphs. (a) Significant cell-graph patterns not found in random graphs. (b) Patterns found equally in random and cell-graphs and are therefore not significant. (c) Histogram of all patterns common among cell-graphs plotted as the absolute difference between frequencies in random versus cell-graphs. Patterns at the extremes indicate significant patterns.
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