Quantification of Spatial Parameters in 3D Cellular Constructs Using Graph Theory
Cell-graph mining extracts metrics which represent the topological changes in 3D cell culture as a function of cell density. The effect of change in cell density from 3.0 105 to 1.0 106 on our graph features was plotted. (a) Average degree. (b) Clustering coefficient. (c) Diameter. (d) Number of edges. (e) Giant connected ratio. (f) Number of connected components over the 24-hour time course. The extracted metrics have been normalized from .
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