HBX-Mediated Migration of HBV-Replicating HepG2 Cells: Insights on Development of Hepatocellular Carcinoma

Figure 3

Cell motility assay: microscopic examination of cells (red dots by staining) migrated from the upper side to the lower side of the collagen-coated membrane (Olympus IX 71 microscope). Representative cells were indicated by arrow heads. (a) HepG2 cells transfected by Wild-type Rac1; (b) HepG2 cells transfected with Rac1^G12V; (c) HepG2 cells transfected by Rac1^T17N; (d) HepG2 cells transfected with Wild-type Rac1 and Wild-type HBV genome; (e) HepG2 cells transfected with Rac1 wt and P-A mutant HBV genome; (f) HepG2 cells transfected with Wild-type HBV genome; (g) HepG2 cells transfected with P-A mutant HBV genome.

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