Identification of the Leishmania major Proteins LmjF07.0430, LmjF07.0440, and LmjF27.2440 as Components of Fatty Acid Synthase II

Figure 1

Similarity of L. major LmjF07.0440 and LmjF07.0430 to their T. brucei homologue, TbHTD2. Explanations for this and Figure 3 are given. Multalin- and Genedoc-based comparison of the deduced amino acid sequences is provided. Dashes indicate the arrangement of the sequences for best fit. Black shadings refer to conserved amino acid residues among all three sequences whereas the darker and lighter grey shadings denote regions with more relaxed residue similarities not necessarily shared by the full set of sequences. MitoProt predictions of cleaved mitochondrial leader sequences are indicated (+). Active site residues of human mitochondrial dehydratase D62 and H67 are denoted (▾), whereas the hydratase 2 domain is underscored (*). The sequences used for the Leishmania proteins throughout this work were retrieved from GeneDB of the Sanger Institute, whereas the accession number for TbHTD2 was Q580H9_9TRYP.