Research Article
SAROTUP: Scanner and Reporter of Target-Unrelated Peptides
Table 1
Known patterns of target-unrelated peptides.
| TUP Category | TUP Pattern | Mechanism in brief |
| Capturing agents | H-P-[QM], G-D-[WF]-x-F, W-x-W-L, E-P- | Binding to streptavidin | D-W-[FY], D-V-E-x-W-[LIV] | W-x-P-P-F-[RK] | Binding to biotin | W-[TS]-[LI]-x(2)-H-[RK] | Binding to Protein A | R-T-[LI]-[TS]-K-P, [LFW]-x-F-Q, W-I-S- | Binding to secondary antibody | x(2)-D-W, Q-[LV]-[LV]-Q, RTYK | Constant region of antibody (the target) | S-S-[IL], GELVW, G-[LI]-T-D-[WY], | Binding to the Fc fragment | [RHK]-P-S-P, P-S-P-[RK] | Screening solid phase | W-x(2)-W, WHWRLPS, F-H-x(2)-W | Binding to plastic | Contaminants in the target sample | F-H-E-x-W-P-[ST] | Binding to contaminant bovine serum albumin | | QSYP | Binding to contaminant bovine IgG | Phage mutation | HAIYPRH | Growing faster than other phages |
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