SAROTUP: Scanner and Reporter of Target-Unrelated Peptides

Table 4

Mimotope-based epitope prediction with or without SAROTUP procedure.

Target	Prediction without SAROTUP procedure	Genuine epitope	Prediction with SAROTUP procedure
cetuximab	N134, E136, S137, I138, Q139, W140, R141, Q164, K185, L186, T187, K188	P349, R353, L382, Q384, Q408, H409, Q411, F412, V417, S418, I438, S440, G441, K443, K465, I467, S468, N469, G471, N473	K375, I401, R403, R405, T406, K407, Q408, H409, G410, Q411, F412, D436
80R	H445, V458, P459, F460, S461, P462, D463, G464, K465, P466, C467, T468, P469, P470, A471, L472, N473, C474, Y475	R426, S432, Y436, K439, Y440, Y442, P469, P470, A471, L472, C474, Y475, W476, L478, N479, D480, G482, Y484, T485, T486, T487, G488,Y491, Q492	L443, R444, H445, I455, S456, N457, V458, P459, F460, S461, P462, D463, G464, K465, P466, C467, T468, P469, P470, A471, L472, N473, C474, Y475
b12	I108, C109, S110, L111, D113, Q114, S115, L116, K117, P118, C119, V120, P206, K207, V208, S209, F210, E211, P212, I213, P214, I251, R252, P253, I424, N425, M426, W427, C428, K429, V430	N280, A281, S365, G366, G367, D368, P369, I371, V372, T373, Y384, N386, P417, R419, V430, G431, K432, T455, R456, G472, G473, D474, M475	W95, T232, F233, N234, T236, S257, L260, N262, G263, S264, L265, A266, E267, E268, E269, V270, V271, T290, S291, S364, S365, G366, G367, D368, P369, E370, I371, V372, T373, T450, S481