Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle

Figure 3

Relation between left ventricular pressure changes during the cardiac cyle and Ca²⁺-binding to cTnC in the myofilament lattice. The onset and end of ejection are indicated. Note that pressure (systolic stiffening or elastance) is maintained despite the fall in bound Ca²⁺. The Ca²⁺ binding kinetics are based on computations described Burkhoff and colleagues [25, 26]. See text for further discussion.