Leishmania Interferes with Host Cell Signaling to Devise a Survival Strategy

Figure 3

STAT1 phosphorylation regulation through IFNγ receptor: infected macrophages display reduced levels of total and phosphorylated JAK1 and JAK2 and attenuate IFN-γ induced STAT-1 phosphorylation in macrophages, aiding the parasites in escaping host immunity. GAS: Interferon gamma-activated site.