Monocyte Chemoattractant Protein-1− 2518 A/G Single Nucleotide Polymorphism Might Be Associated with Renal Disease and Thrombocytopenia of SLE

Table 1

Association of the MCP-1 –2518 A>G polymorphism with clinical manifestation in patients with SLE.

Characteristic	Genotypes distribution
	A/A (103)(a)	A/G (80)(a)	G/G (16)(a)	Odds ratio (95% CI), P (e)
Malar rash	46	39	6
Discoid rash	32	23	5
Photosensitivity	47	38	7
Oral ulcers	41	32	6
Arthritis	59	42	8
Serositis	18	13	3
Renal	39	44	12	3.614 (1.123–11.631, 𝑃=0.0345)(b); 2.297 (1.301–4.057, 𝑃=0.0046)(c); 4.923 (1.483–16.343, 𝑃=0.0067)(d)
Neurologic symptoms	19	16	4
Hematologic symptoms	28	23	6
Thrombocytopenia	14	23	5	2.618 (1.280–5.352, 𝑃=0.0089)(c)
Leukopenia	21	16	3
Immunologic symptoms	51	43	7
ANA	103	80	16

(a)represents the absolute number of positive patients for A/A, A/G, A/G genotypes, respectively.
Comparison genotype (b)(G/G versus A/A and A/G); (c)(G/G and A/G versus A/A); (d)(G/G versus A/A), between patients with and patients without a manifestation was performed by (e)Fisher exact test.