Table 4: Hepatitis C Immune Escape Tricks [8, 9, 23].

(i)Viral sequence mutations allow escape of both Ab and T cell recognition (NB high replication rate)
(ii)HCV core protein binds a complement protein that results in downregulation of IL-12 production and affects T cell induction
(iii)Express a protease which interrupts induction of interferon a/b
(iv)Incomplete differentiation of HCV-specific T cells may occur (like chronic memory cells)
(v)Induction of IL-10-producing Treg cells
(vi)Also an involvement of CD4 + CD25 + natural Tregs