Bioimaging of Nucleolin Aptamer-Containing 5-(N-benzylcarboxyamide)-2′-deoxyuridine More Capable of Specific Binding to Targets in Cancer Cells

Figure 4

Fluorescence analysis of numbers 29, 41, 12, and 26, Cy3-AS1411, and the mutant form of AS1411 labeled with Cy3. (a) Quantitative fluorescence intensity in HeLa and CHO cells. Data are represented as means ± standard error of means (^∗𝑃<.05,^∗∗𝑃<.005 unpaired 𝑡-test). (b) Confocal microscopy imaging in HeLa cells. (c) Confocal microscopy imaging in CHO cells. (d) Antiproliferation effects were measured by MTT assay. 4 𝜇M of each compounds was treated at 2×10⁵ C6 cells per well. Data are represented as means ± standard error of means (^∗∗𝑃<.005 unpaired 𝑡-test).

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