BALB/c Mice Vaccinated with Leishmania major Ribosomal Proteins Extracts Combined with CpG Oligodeoxynucleotides Become Resistant to Disease Caused by a Secondary Parasite Challenge
(a) Course of L. major infection in protected and reinfected BALB/c mice. Values represent the mean lesion diameter±standard deviation (SD). *: significant differences in inflammation for protected versus control mice at week seven postchallenge. (b) Seven weeks after reinfection, mice were euthanized and parasite burden in the ear dermis, spleen and in the retromaxillar DLN was individually quantitated. Results are expressed as the mean±SD of twelve ears and six spleens and DLN. *: significant decrease for reinfected versus control mice. (c) The parasite burden at week seven after rechallenge was individually quantitated in the popliteal lymph nodes of control and reinfected mice. Results are expressed as the mean±SD of six DLN. *: significant decrease for reinfected versus control mice.
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