Physiological and Histopathological Investigations on the Effects of -Lipoic Acid in Rats Exposed to Malathion
Table 1
Changes in values of serum GOT, GPT, ALP, ACP, total protein, total albumin, creatinine, urea, and uric acid in rats treated with malathion, malathion plus -lipoic acid, and -lipoic acid. Tabulated values are means of ten determinations standard deviation (SD).
Parameters
Treatment
Control
Malathion
Malathion -Lipoic acid
-lipoic acid
GOT ()
61.80 3.29
189.40 13.6
115.30 5.
56.70 6.52
GPT ()
39.50 3.17
112.70 9.9
64.30 7.8
38.20 2.52
ALP ()
324.40 10.86
632.70 29.8
395.30 37.0
339.20 20.61
ACP ()
109.80 9.25
166.40 27.6
139.30 17.1
114.20 13.58
Total protein (g 100 m)
6.75 0.28
5.51 0.3
6.64 0.38
6.73 0.28
Total albumin (g 100 m)
3.18 0.19
2.86 0.2
3.13 0.23
3.24 0.25
Creatinine (mg 100 m)
0.67 0.05
1.16 0.2
0.82 0.1
0.70 0.08
Urea (mg 100 m)
23.56 1.77
30.12 2.4
25.28 1.92
22.74 2.04
Uric acid (mg 100 m)
3.71 0.27
4.90 0.4
4.01 0.36
3.86 0.26
a: Indicates a significant difference between control and treated groups. b: Indicates a significant difference between the group treated with malathion and groups treated with malathion plus -lipoic acid and -lipoic acid.