Bioassay-Guided Evaluation of Antinociceptive Effect of N-Salicyloyltryptamine: A Behavioral and Electrophysiological Approach

Table 1

Effect of NST or morphine on acetic acid-induced writhing.

Treatment	Dose (mg/kg)	Number of writhingsa	% Inhibition
Vehicle	—	39.4 ± 7.9	—
NST	100	14.1 ± 7.2c	64.2e
NST	200	12.9 ± 6.3c	67.3e
NST + naloxone	100 + 1.5	21.8 ± 7.7b	44.7e
NST + naloxone	200 + 1.5	18.1 ± 9.4b	50.1e
Morphine	5	1.3 ± 0.6d	96.7f
Morphine + naloxone	5 + 1.5	35.2 ± 5.8	10.7

n = 10 per group.
aValues represent mean ± S.E.M.
^b𝑃<.05 (one-way ANOVA and Dunnett’s test), significantly different from control.
^c𝑃<.01 (one-way ANOVA and Dunnett’s test), significantly different from control.
^d𝑃<.001 (one-way ANOVA and Dunnett’s test), significantly different from control.
^e𝑃<.01 (Fisher’s test), significantly different from control.
^f𝑃<.001 (Fisher’s test), significantly different from control.