Bioassay-Guided Evaluation of Antinociceptive Effect of N-Salicyloyltryptamine: A Behavioral and Electrophysiological Approach

Table 2

Effect of NST or indomethacin on formalin-induced pain.

Treatment	Time of nociceptive behavior (s)
	0–5 min		15–30 min
	Score of paina	% inhibition	Score of paina	% inhibition
Vehicle	92.3 ± 24.4	—	124.2 ± 23.1	—
NST (100 mg/kg)	43.8 ± 16.1b	52.5d	58.1 ± 17.3b	53.2d
NST (200 mg/kg)	39.9 ± 21.7b	56.8d	46.4 ± 13.2a	62.6d
Indomethacin (10 mg/kg)	78.4 ± 18.9	15.1	14.9 ± 8.9c	88.0e

n = 10 per group.
aValues represent mean [total time spent in licking (s)] ± S.E.M.
^b𝑃<.05 (one-way ANOVA and Dunnett’s test), significantly different from control.
^c𝑃<.001 (one-way ANOVA and Dunnett’s test), significantly different from control.
^d𝑃<.01 (Fisher’s test), significantly different from control.
^e𝑃<.001 (Fisher’s test), significantly different from control.