Mechanisms of the Regulation of the Intestinal Exchanger NHE3
Figure 2
NHE3 can be regulated via interaction with different proteins. A tentative model of regulation of NHE3 by IRBIT and NHERF2 is shown as an example. NHE3 is retrieved into a cytoplasmic pool by a mechanism dependent on NHERF2-PKC-actinin-4 [53]. IRBIT stimulates NHE3 activity by inducing exocytic trafficking of NHE3 to the surface membrane (adapted from He et al. [111]).
