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DC subset | Organ | Functional characteristics | References |
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*CD11b+ DCs (1) **CD8+ DCs (2) ***DN DCs (3) | Peyer’s patches | (1) During infection recruited to FAE from subepithelial dome. (2) Produce IL-10. (3) Produce IL-12 and drive IFN by T cells. | [2, 3, 19] |
*CD11b+ DCs **CD8+ DCs ***DN DCs CD8 CD103+ | Mesenteric lymph nodes | CD11b+ cells show higher capacity to secrete IL-10 and prime Th2 cells. CD103+ DC migrate from LP in a CCR7 dependent manner. | [3, 28, 35] |
CD11b+ CD8 CD103+ | Lamina propria | Constitutive expression of IL-10 and IFN-. Extend their dendrites to sample bacteria through epithelial cell tight junctions. | [26] |
CD11b+DCs CD8+ CD103+DCs CD8a- CD11 CD11b+ CD103+ | Colon | Constitutive expression of IL-10. Maintenance of T cell homeostasis. Concentrated in isolated lymphoid follicles (ILFs) few in lamina propria. | [2] |
MHCII+ Dec 205+,Dec 207, CD14, CD16/32 | Muscularis layer | Not known. Possible correlation with increasing number of commensal bacteria. | [23] |
CD11c+, MHCII+ (Lymphatic or “veiled” DCs) | Lymphatic vessels draining the intestine | Transport of apoptotic bodies from intestinal epithelial cells to regional lymph nodes. | [36] |
B220+ (plasmacytoid DCs) | Peyer’s patches, Mesenteric Lymph nodes, and Lamina Propria (small intestine and colon) | PPs: production of type I IFN regulated by IL-10, TGF-, and prostaglandin E2. MLN: induction of T regs. | [34, 37] |
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