Table 1: Intestinal DC subsets.

DC subsetOrganFunctional characteristicsReferences

*CD11b+ DCs (1) **CD8 𝛼 + DCs (2) ***DN DCs (3) Peyer’s patches(1) During infection recruited to FAE from subepithelial dome. (2) Produce IL-10. (3) Produce IL-12 and drive IFN 𝛾 by T cells.[2, 3, 19]
*CD11b+ DCs **CD8 𝛼 + DCs ***DN DCs CD8 𝛼 i n t CD103+Mesenteric lymph nodesCD11b+ cells show higher capacity to secrete IL-10 and prime Th2 cells. CD103+ DC migrate from LP in a CCR7 dependent manner. [3, 28, 35]
CD8 𝛼 i n t CD103+
Lamina propriaConstitutive expression of IL-10 and IFN- 𝛽 . Extend their dendrites to sample bacteria through epithelial cell tight junctions.[26]
CD11b+DCs CD8 𝛼 + CD103+DCs CD8a- CD11 b l o CD11b+ CD103+ColonConstitutive expression of IL-10. Maintenance of T cell homeostasis. Concentrated in isolated lymphoid follicles (ILFs) few in lamina propria.[2]
MHCII+ C D 1 1 c m i d Dec 205+,Dec 207, CD14, CD16/32 Muscularis layerNot known. Possible correlation with increasing number of commensal bacteria.[23]
CD11c+, MHCII+ (Lymphatic or “veiled” DCs)Lymphatic vessels draining the intestineTransport of apoptotic bodies from intestinal epithelial cells to regional lymph nodes.[36]
C D 1 1 c m i d B220+ (plasmacytoid DCs)Peyer’s patches, Mesenteric Lymph nodes, and Lamina Propria (small intestine and colon)PPs: production of type I IFN regulated by IL-10, TGF- 𝛽 , and prostaglandin E2. MLN: induction of T regs. [34, 37]

C D 1 1 c + CD11 b +  CD8 𝛼 (CD11 b + ).
**CD11 c +  CD11 b CD8 𝛼 + (CD8 𝛼 + ).
***CD11 c +  CD11 b CD8 𝛼 (double negative: DN).