Autocrine, Not Paracrine, Interferon-Gamma Gene Delivery Enhances Ex Vivo Antigen-Specific Cytotoxic T Lymphocyte Stimulation and Killing
Secretion of IFN- from AAV-transduced cells over time. Cells were treated as indicated and secretion of IFN-γ was measured in the conditioned medium at the indicated time by ELISA. The conditions include AAV/IFN- delivery into DC (with concurrent AAV/CEA delivery), (a); AAV/IFN- delivery into T cells, (b); AAV/IFN- only delivery into DC, (c); cells with no treatment, (d).
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