Autocrine, Not Paracrine, Interferon-Gamma Gene Delivery Enhances Ex Vivo Antigen-Specific Cytotoxic T Lymphocyte Stimulation and Killing
Enhanced CTL killing by IFN- autocrine delivery. (a) shows CTL killing after the indicated treatment, of CEA-positive targets, SW480 cells, by standard release assay. All assays were done at a effector: target ratio of 20 : 1. Note that AAV/IFN- autocrine delivery resulted in CTL with the highest killing ability. (b) shows a similar CTL killing assay using CEA+ LCL cells as the target. Note that, again, AAV/IFN- autocrine delivery resulted in CTL with the highest killing ability.
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