BioMed Research International / 2010 / Article / Tab 2

Research Article

Autocrine, Not Paracrine, Interferon-Gamma Gene Delivery Enhances Ex Vivo Antigen-Specific Cytotoxic T Lymphocyte Stimulation and Killing

Table 2

Characterization T cell subsets and cytokine expression as percentages, from AAV-infected DC (top panel) and rAAV-infected T cells (bottom panel).

DC treatmentCD8+/CD4 IFN- 𝛾 /IL4CD69+, CD8+CD25+, CD4+

Ctrl (mock) 21.6/51.321.85/10.75 27.4 55.6
AAV/CEA 50.3/22.1 26.53/2.73 61.5 16.2
AAV/CEA + exogen IFN- 𝛾 52.1/23.618.84/2.46 60.8 15.6
AAV/CEA + AAV/ IFN- 𝛾 56.5/22.5 27.71/2.90 64.7 14.3

T cell treatmentCD8+/CD4+IFN- 𝛾 /IL4CD69+, CD8+CD25+, CD4+

AAV/IFN- 𝛾 84.6/10.7 43.4/2.37 91.3 17.1
exogen IFN- 𝛾 ND 24.28/1.96 ND ND
Untreated T cells 14.1/69.8 26.53/2.73 20.5 63.5

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