Maintenance or Emergence of Chronic Phase Secondary Cytotoxic T Lymphocyte Responses after Loss of Acute Phase Immunodominant Responses Does Not Protect SIV-Infected Rhesus Macaques from Disease Progression
Figure 2
Viral Evolution in an Animal with Known Protective Mamu Alleles. (a) Comparison of IFN-γ ELISPOT values for the vaccinated, Mamu 01 + NP animal 16040 before or after the Mamu 01-restricted Gag CTPYDINQM to CIPYDINQM, Tat STPESANL to PTPESANP, and Pol STPPLVRLV to SSPPLVRLV mutations. Statistical analysis was performed using the Mann Whitney test. (b) NASBA viral loads and IFN- ELISPOT results for all three epitopes were plotted to determine the effects of mutations on the control of viral replication.
