A Multifactorial Mechanism in the Superior Antimalarial Activity of -C-GalCer
Figure 1
Structural comparison between -C-GalCer and -GalCer showing the main differences between the two molecules. Glycoside CH2 is nonpolar and hydrophobic; it repels hydrogen bond donors. In contrast, glycoside oxygen is polar, and the electron pairs can form hydrogen bonds with N–H or O–H donors.