Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 283612, 11 pages
http://dx.doi.org/10.1155/2010/283612
Research Article

A Multifactorial Mechanism in the Superior Antimalarial Activity of -C-GalCer

1Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA
2Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
3Department of Chemistry, Hunter College, New York, NY 10021, USA
4Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Institute, New York, NY 10065, USA
5HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, New York, NY 10016, USA

Received 28 August 2009; Accepted 4 October 2009

Academic Editor: Abhay R. Satoskar

Copyright © 2010 John Schmieg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Nussenzweig and R. S. Nussenzweig, “Rationale for the development of an engineered sporozoite malaria vaccine,” Advances in Immunology, vol. 45, pp. 283–334, 1989. View at Google Scholar · View at Scopus
  2. J. Schmieg, G. Gonzalez-Aseguinolaza, and M. Tsuji, “The role of natural killer T cells and other T cell subsets against infection by the pre-erythrocytic stages of malaria parasites,” Microbes and Infection, vol. 5, no. 6, pp. 499–506, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Kronenberg, “Toward an understanding of NKT cell biology: progress and paradoxes,” Annual Review of Immunology, vol. 23, pp. 877–900, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Tsuji, “Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands,” Cellular and Molecular Life Sciences, vol. 63, no. 16, pp. 1889–1898, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Gonzalez-Aseguinolaza, C. de Oliveira, M. Tomaska et al., “a-galactosylceramide-activated Va14 natural killer T cells mediate protection against murine malaria,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 15, pp. 8461–8466, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Schmieg, G. Yang, R. W. Franck, and M. Tsuji, “Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand α-galactosylceramide,” Journal of Experimental Medicine, vol. 198, no. 11, pp. 1631–1641, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Schmieg, G. Yang, R. W. Franck, N. van Rooijen, and M. Tsuji, “Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 4, pp. 1127–1132, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. S.-I. Fujii, K. Shimizu, H. Hemmi et al., “Glycolipid a-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 30, pp. 11252–11257, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Yang, J. Schmieg, M. Tsuji, and R. W. Franck, “The C-glycoside analogue of the immunostimulant α-galactosylceramide (KRN7000): synthesis and striking enhancement of activity,” Angewandte Chemie International Edition, vol. 43, no. 29, pp. 3818–3822, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. O. Brua-Romero, J. C. R. Hafalla, G. Gonzalez-Aseguinolaza, G.-I. Sano, M. Tsuji, and F. Zavala, “Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR,” International Journal for Parasitology, vol. 31, no. 13, pp. 1499–1502, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Chomczynski and N. Sacchi, “Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction,” Analytical Biochemistry, vol. 162, no. 1, pp. 156–159, 1987. View at Google Scholar · View at Scopus
  12. M. J. Smyth, N. Y. Crowe, and D. I. Godfrey, “NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma,” International Immunology, vol. 13, no. 4, pp. 459–463, 2001. View at Google Scholar · View at Scopus
  13. A. O'Garra and N. Arai, “The molecular basis of T helper 1 and T helper 2 cell differentiation,” Trends in Cell Biology, vol. 10, no. 12, pp. 542–550, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Sharif, G. A. Arreaza, P. Zucker et al., “Activation of natural killer T cells by a-galactosylceramide treatment prevents the onset and recurrence of autoimmune type 1 diabetes,” Nature Medicine, vol. 7, no. 9, pp. 1057–1062, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. A. K. Singh, M. T. Wilson, S. Hong et al., “Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis,” Journal of Experimental Medicine, vol. 194, no. 12, pp. 1801–1811, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. A. D'Andrea, M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri, “Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells,” Journal of Experimental Medicine, vol. 178, no. 3, pp. 1041–1048, 1993. View at Google Scholar · View at Scopus
  17. M. Aste-Amezaga, X. Ma, A. Sartori, and G. Trinchieri, “Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10,” Journal of Immunology, vol. 160, no. 12, pp. 5936–5944, 1998. View at Google Scholar · View at Scopus
  18. K.-I. Seino, M. Harada, and M. Taniguchi, “NKT cells are relatively resistant to apoptosis,” Trends in Immunology, vol. 25, no. 5, pp. 219–221, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. M. T. Wilson, C. Johansson, D. Olivares-Villagomez et al., “The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 19, pp. 10913–10918, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Y. Crowe, A. P. Uldrich, K. Kyparissoudis et al., “Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells,” Journal of Immunology, vol. 171, no. 8, pp. 4020–4027, 2003. View at Google Scholar · View at Scopus
  21. M. Harada, K.-I. Seino, H. Wakao et al., “Down-regulation of the invariant Va14 antigen receptor in NKT cells upon activation,” International Immunology, vol. 16, no. 2, pp. 241–247, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Schumann, R. B. Voyle, B.-Y. Wei, and H. R. MacDonald, “Cutting edge: influence of the TCR Vβ domain on the avidity of CD1d: α-galactosylceramide binding by invariant Vα14 NKT cells,” Journal of Immunology, vol. 170, no. 12, pp. 5815–5819, 2003. View at Google Scholar · View at Scopus
  23. A. K. Stanic, R. Shashidharamurthy, J. S. Bezbradica et al., “Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural TCR,” Journal of Immunology, vol. 171, no. 9, pp. 4539–4551, 2003. View at Google Scholar · View at Scopus
  24. S. Valitutti, S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia, “Serial triggering of many T-cell receptors by a few peptide-MHC complexes,” Nature, vol. 375, no. 6527, pp. 148–151, 1995. View at Google Scholar · View at Scopus
  25. Z. Cai, H. Kishimoto, A. Brunmark, M. R. Jackson, P. A. Peterson, and J. Sprent, “Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells,” Journal of Experimental Medicine, vol. 185, no. 4, pp. 641–651, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. J. L. Matsuda, L. Gapin, J. L. Baron et al., “Mouse Va14i natural killer T cells are resistant to cytokine polarization in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 14, pp. 8395–8400, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Kitamura, K. Iwakabe, T. Yahata et al., “The natural killer T (NKT) cell ligand a-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells,” Journal of Experimental Medicine, vol. 189, no. 7, pp. 1121–1127, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Tomura, W.-G. Yu, H.-J. Ahn et al., “A novel function of Va14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system,” Journal of Immunology, vol. 163, no. 1, pp. 93–101, 1999. View at Google Scholar · View at Scopus
  29. Y.-F. Yang, M. Tomura, S. Ono, T. Hamaoka, and H. Fujiwara, “Requirement for IFN-γ in IL-12 production induced by collaboration between Vα14+ NKT cells and antigen-presenting cells,” International Immunology, vol. 12, no. 12, pp. 1669–1675, 2000. View at Google Scholar · View at Scopus
  30. S.-I. Fujii, K. Shimizu, C. Smith, L. Bonifaz, and R. M. Steinman, “Activation of natural killer T cells by α-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein,” Journal of Experimental Medicine, vol. 198, no. 2, pp. 267–279, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. S.-I. Fujii, K. Liu, C. Smith, A. J. Bonito, and R. M. Steinman, “The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation,” Journal of Experimental Medicine, vol. 199, no. 12, pp. 1607–1618, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Rosette, G. Werlen, M. A. Daniels et al., “The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model,” Immunity, vol. 15, no. 1, pp. 59–70, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Sloan-Lancaster and P. M. Allen, “Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology,” Annual Review of Immunology, vol. 14, pp. 1–27, 1996. View at Publisher · View at Google Scholar · View at Scopus
  34. A. E. Nel and N. Slaughter, “T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy,” Journal of Allergy and Clinical Immunology, vol. 109, no. 6, pp. 901–915, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Valitutti and A. Lanzavecchia, “Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition,” Immunology Today, vol. 18, no. 6, pp. 299–304, 1997. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Rachmilewitz and A. Lanzavecchia, “A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding,” Trends in Immunology, vol. 23, no. 12, pp. 592–595, 2002. View at Publisher · View at Google Scholar · View at Scopus