Gene Transfer into the Lung by Nanoparticle Dextran-Spermine/Plasmid DNA Complexes

Figure 7

Luciferase expression (RLU/mg protein) in the trachea and lung of BALB/c mice following the administration of D-SPM/pDNA at ratio 16, containing 13.5 𝜇g pDNA with succeeding readministration post 24 h of first dosing. The vertical arrow pointing downward indicates the time point of readministration after the initial administration. The horizontal dash line represents the approximate sensitivity of the assay. Data are presented as mean ± S.E.M from 6 animals.