Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 290516, 8 pages
http://dx.doi.org/10.1155/2010/290516
Research Article

Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor

1Consolidated Research Institute for Advanced Science and Medical Care (ASMeW), Waseda University, Tokyo 169-8050, Japan
2Division of Ultrafine Structure, Department of Pathology, Research Institute of International Medical Center of Japan, Toyama 1-21-1, Shinjuku-ku, Tokyo 162-8655, Japan
3Faculty of Science and Engineering, Waseda University, Tokyo 169-8555, Japan
4Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639, Japan
5Tea Solutions, Food Research Lab, Hara Office Inc, Miyabara, Fujieda City 130-0012, Japan

Received 10 November 2010; Accepted 29 December 2010

Academic Editor: Gary E. Gallick

Copyright © 2010 Hoang Anh Vu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Maxwell Parkin, F. Bray, J. Ferlay, and P. Pisani, “Estimating the world cancer burden: Globocan 2000,” International Journal of Cancer, vol. 94, no. 2, pp. 153–156, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. T. P. Hecker and C. L. Gladson, “Focal adhesion kinase in cancer,” Frontiers in Bioscience, vol. 8, pp. s705–s714, 2003. View at Google Scholar · View at Scopus
  3. D. J. Sieg, C. R. Hauck, D. Ilic et al., “FAK integrates growth-factor and integrin signals to promote cell migration,” Nature Cell Biology, vol. 2, no. 5, pp. 249–256, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. V. M. Golubovskaya, S. Gross, A. S. Kaur et al., “Simultaneous inhibition of focal adhesion kinase and Src enhances detachment and apoptosis in colon cancer cell lines,” Molecular Cancer Research, vol. 1, no. 10, pp. 755–764, 2003. View at Google Scholar · View at Scopus
  5. W. Liu, D. A. Bloom, W. G. Cance, E. V. Kurenova, V. M. Golubovskaya, and S. N. Hochwald, “FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells,” Carcinogenesis, vol. 29, no. 6, pp. 1096–1107, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. T. W. Bauer, R. J. Somcio, F. Fan et al., “Regulatory role of c-Met in insulin-like growth factor-I receptor—mediated migration and invasion of human pancreatic carcinoma cells,” Molecular Cancer Therapeutics, vol. 5, no. 7, pp. 1676–1682, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Hakam, Q. Fang, R. Karl, and D. Coppola, “Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma,” Digestive Diseases and Sciences, vol. 48, no. 10, pp. 1972–1978, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Moser, P. Schachtschneider, S. A. Lang et al., “Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis,” European Journal of Cancer, vol. 44, no. 11, pp. 1577–1586, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Watanabe, M. Takaoka, K. Sakurama et al., “Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo,” Clinical Cancer Research, vol. 14, no. 14, pp. 4631–4639, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. TA. J. Liu, T. LaFortune, T. Honda et al., “Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo,” Molecular Cancer Therapeutics, vol. 6, no. 4, pp. 1357–1367, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Faucheux, R. Schweiss, K. Lützow, C. Werner, and T. Groth, “Self-assembled monolayers with different terminating groups as model substrates for cell adhesion studies,” Biomaterials, vol. 25, no. 14, pp. 2721–2730, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. H. A. Vu, P. T. Xinh, M. Masuda et al., “FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation,” Leukemia, vol. 20, no. 8, pp. 1414–1421, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. B. D. Cox, M. Natarajan, M. R. Stettner, and C. L. Gladson, “New concepts regarding focal adhesion kinase promotion of cell migration and proliferation,” Journal of Cellular Biochemistry, vol. 99, no. 1, pp. 35–52, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Shintani, Y. Fukumoto, N. Chaika, R. Svoboda, M. J. Wheelock, and K. R. Johnson, “Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor,” Journal of Cell Biology, vol. 180, no. 6, pp. 1277–1289, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Inaba, Y. Nagaoka, Y. Kushima et al., “Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (-)-epigallocatechin against HCT116 colorectal carcinoma cells,” Biological and Pharmaceutical Bulletin, vol. 31, no. 1, pp. 79–84, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Pyrzynska, M. Serrano, C. Martínez-A, and B. Kaminska, “Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A,” Journal of Biological Chemistry, vol. 277, no. 16, pp. 14102–14108, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Basu and S. Haldar, “Combinatorial effect of epigallocatechin-3-gallate and TRAIL on pancreatic cancer cell death,” International Journal of Oncology, vol. 34, no. 1, pp. 281–286, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Qanungo, M. Das, S. Haldar, and A. Basu, “Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells,” Carcinogenesis, vol. 26, no. 5, pp. 958–967, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Stephan, A. Musacchio, and Y. Hagos, “Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cδ,” Cancer Research, vol. 69, no. 4, pp. 1350–1357, 2009. View at Publisher · View at Google Scholar
  20. K. M. Rieger-Christ, R. Hanley, C. Lodowsky et al., “The green tea compound, (-)-epigallocatechin-3-gallate downregulates N-cadherin and suppresses migration of bladder carcinoma cells,” Journal of Cellular Biochemistry, vol. 102, no. 2, pp. 377–388, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Shintani, M. A. Hollingsworth, M. J. Wheelock, and K. R. Johnson, “Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH-terminal kinase 1 and up-regulating N-cadherin expression,” Cancer Research, vol. 66, no. 24, pp. 11745–11753, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Li, Z. He, S. Ermakova et al., “Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation,” Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 3, pp. 598–605, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. J. Weyant, A. M. Carothers, A. J. Dannenberg, and M. M. Bertagnolli, “(+)-catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the Min/+ mouse,” Cancer Research, vol. 61, no. 1, pp. 118–125, 2001. View at Google Scholar · View at Scopus
  24. J. McLarty, R. L. H. Bigelow, M. Smith, D. Elmajian, M. Ankem, and J. A. Cardelli, “Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro,” Cancer Prevention Research, vol. 2, no. 7, pp. 673–682, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. T. D. Shanafelt, T. G. Call, C. S. Zent et al., “Phase I trial of daily oral polyphenon E in patients with asymptomatic rai stage 0 to II chronic lymphocytic leukemia,” Journal of Clinical Oncology, vol. 27, no. 23, pp. 3808–3814, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. K. R. Landis-Piwowar, C. Huo, DI. Chen et al., “A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent,” Cancer Research, vol. 67, no. 9, pp. 4303–4310, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. M. E. Stearns, M. D. Amatangelo, D. Varma, C. Sell, and S. M. Goodyear, “Combination therapy with epigallocatechin-3-gallate and doxorubicin in human prostate tumor modeling studies: inhibition of metastatic tumor growth in severe combined immunodeficiency mice,” American Journal of Pathology, vol. 177, no. 6, pp. 3169–3179, 2010. View at Publisher · View at Google Scholar
  28. C. Almoguera, D. Shibata, K. Forrester, J. Martin, N. Arnheim, and M. Perucho, “Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes,” Cell, vol. 53, no. 4, pp. 549–554, 1988. View at Google Scholar · View at Scopus
  29. E. S. Calhoun, J. B. Jones, R. Ashfaq et al., “BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets,” American Journal of Pathology, vol. 163, no. 4, pp. 1255–1260, 2003. View at Google Scholar · View at Scopus
  30. L. L. Siu, A. Awada, C. H. Takimoto et al., “Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer,” Clinical Cancer Research, vol. 12, no. 1, pp. 144–151, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. H. A. Vu, Y. Beppu, H. T. Chi et al., “Green tea epigalocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via inhibition of both FAK and IGF-1R,” IFMBE Proceedings, vol. 27, pp. 223–226, 2010. View at Google Scholar