Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188

<table>Altered haemolysis after the application of one rectangular pulse of 3 <svg height="13.9375" id="M50" style="vertical-align:-0.13792pt" version="1.1" viewbox="0 0 63.325001 13.9375" width="63.325001" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.9375)">
<g transform="translate(72,-60.85)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">k</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">V</tspan>
<tspan style="font-size: 12.50px; " x="18.054333" y="0">⋅</tspan>
<tspan style="font-size: 12.50px; " x="24.405855" y="0">c</tspan>
<tspan style="font-size: 12.50px; " x="29.957188" y="0">m</tspan>
</text>
<text transform="matrix(1,0,0,-1,-32.26,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">−</tspan>
<tspan style="font-size: 8.75px; " x="5.99512" y="0">1</tspan>
</text>
</g>
</g>
</svg> and duration 0.5 ms in the presence of 10 <svg height="9.6750002" id="M51" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜇</tspan>
</text>
</g>
</g>
</svg>M poloxamer 188. <svg height="11.325" id="M52" style="vertical-align:-0.51414pt" version="1.1" viewbox="0 0 42.974998 11.325" width="42.974998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.325)">
<g transform="translate(72,-62.94)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">+</tspan>
<tspan style="font-size: 12.50px; " x="8.5645552" y="0">P</tspan>
<tspan style="font-size: 12.50px; " x="15.528726" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="21.780226" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="28.031727" y="0">8</tspan>
</text>
</g>
</g>
</svg> indicates that erythrocytes were electroporated in the presence of 10 <svg height="9.6750002" id="M53" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜇</tspan>
</text>
</g>
</g>
</svg>M P188, and <svg height="13.45" id="M54" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 46.099998 13.45" width="46.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.45)">
<g transform="translate(72,-61.24)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">+</tspan>
<tspan style="font-size: 12.50px; " x="8.5645552" y="0">|</tspan>
<tspan style="font-size: 12.50px; " x="11.065155" y="0">P</tspan>
<tspan style="font-size: 12.50px; " x="18.029325" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="24.280827" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="30.532326" y="0">8</tspan>
</text>
</g>
</g>
</svg> (10 <svg height="9.6750002" id="M55" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝜇</tspan>
</text>
</g>
</g>
</svg>M) indicates the addition of P188 after the electrical pulse.</table>

BioMed Research International

fig5

Figure 5

Figure 5: Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188 