Genetic Risk for Recurrent Urinary Tract Infections in Humans: A Systematic Review

Table 3

Comparison of the gene expression of patients with recurrent urinary tract infection and controls. (CXCR: IL-8 receptors; MyD88: myeloid differentiation primary response gene 88; SIGIRR:single immunoglobulin domain-containing IL-1 receptor–related molecule; TLR: Toll-like receptor; TRAM: TIR domain–containing adaptor inducing IFN-β-related adaptor molecule; TRIF: TIR domain–containing adaptor inducing INF-β).

Protein expression	Patients/controls (N/N)	Patient values (range or ±SD)	Control value (range or ± SD)	P	References
CXCR1	12/12	0.33 ± 0.23	1.33 ± 0.64	<.05	[13, 16]
	60/226	−1.44 [−6.52-(1.04)]^∗	0.28 [−0.73-(2.15)]^∗	<.0001	[18]
	10/15	70% (42%–96%)	100% (77%–165%)	.0006	[19]
	20/30	118.9 (102.7–158.9) AU	116.2 (103.7–139.5) AU	NS	[20]
CXCR2	20/30	14.9 (12.82–17.23) AU	18.9 (16.2–23.6) AU	.002	[20]
TLR4	17/24	33.2 (4.3–74.3)	56.1 (19.2–87.6)	.003
MyD88		100.5 (9.3–197.3)	84.3 (9.9–168.5)	NS
TRIF		139 (34.5–315.1)	85.1 (12.4–171.5)	.02	[23]
TRAM		107.9 (32–262.9)	101.7 (39.8–269.2)	NS
SIGIRR		14.9 (8.2–63.3)	21.9 (12.5–35.5)	.0005

Legend∶^∗∶ compared to a standard; AU∶ arbitrary unit.