A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis

Table 1

Biomarkers for pertussis vaccine toxicity.

Category	Accession no.	Symbol	Brief description
Inflammation	NM_053587	S100A9	A calcium binding protein that may be associated with acute inflammatory processes, coupled with S100a8
	NM_053822	S100A8	May play a role in inflammatory responses such as cell motility, coupled with S100a9
	NM_019323	MCPT9	A serine protease expressed in mast cells, but the precise function has not yet been determined
	NM_031530	CCL2	A ligand for CCR2 that acts as a chemoattractant of monocytes
IFN inducible, immune response	NM_001033691	IRF7	Unknown
	NM_134350	MX2	Involved in inhibiting vesicular stomatitis virus
	NM_203410	IFI27	Induced by steroid hormone, IFN, and LPS in endometrium at implantation, dendric cells, and macrophases
	NM_001007694	IFIT3	May induced by IFN or virus infection
	Y07704	BEST5	Induced by IFN and involved in bone formation
Peptidoglycan metabolism	NM_031055	MMP9	Metalloproteinase involved in extracellular matrix remodeling, bone resorption, and immune responses
	NM_022221	MMP8	May play a role in appositional bone formation and regulation of the extracellular matrix
Xenobiotic metabolism	J02627	CYP2E1	Protects hepatocytes from stress-induced cell death
Others	NM_001106862	NGP	Unknown