Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia
Figure 6
Log-linear, likelihood-ratio association analysis between 29 regulatory SNPs from 12 cell-cycle genes and childhood pre-B acute lymphoblastic leukemia (ALL). Log-linear regression analysis was performed in LEM using 203 case-triads, 118 unrelated ALL patients and 329 controls. Results of the likelihood-ratio chi-square tests ( log ) are shown for the single-step Child (blue) and Mother (red) tests. Mating symmetry (i.e., six mating-type parameters) was assumed at all loci but variants rs1144944 and rs3730485 of the MDM2 gene, as well as CDKN2B rs2069416 for which MA models (nine mating-type parameters) were used to test for association. Horizontal reference line indicates value ofโโ.05. Note that for the tri-allelic variant CDKN2B rs2069416 (A T,C) individuals were grouped according to their T allele such that TT. See Supplementary Table for complete likelihood-ratio chi-square test results.
