Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia

Table 2

The eight simulation models used for evaluation of the fetomaternal association tests.

Model	Child effect	Mother effect	MAF	Δ𝐶
1	—	—	0.05 to 0.25	MS
2	GC11 = 1; GC12 = 2; GC22 = 3	—	0.05 to 0.25	MS
3	—	GM11 = 1; GM12 = 2; GM22 = 3	0.05 to 0.25	MS
4	GC11 = 1; GC12 = 2; GC22 = 3	GM11 = 1; GM12 = 2; GM22 = 3	0.05 to 0.25	MS
5	—	—	0.3	0 to 1
6	GC11 = 1; GC12 = 2; GC22 = 3	—	0.3	0 to 1
7	—	GM11 = 1; GM12 = 2; GM22 = 3	0.3	0 to 1
8	GC11 = 1; GC12 = 2; GC22 = 3	GM11 = 1; GM12 = 2; GM22 = 3	0.3	0 to 1

(–): indicates a null risk model where the genotype relative risks (GRRs) are GRR₁₁ = GRR₁₂ = GRR₂₂ = 1. GC indicates Child genotype relative risk; GM, Mother genotype relative risk; MAF: Minor allele frequency; Δ𝐶: mating-pair disequilibrium. MS indicates mating symmetry where Δ𝐶 = 0.