Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis

Table 4

Molecular networks constituted by the predicted miRNA targets. The list of differentially expressed miRNAs was directly uploaded in IPA and an analysis was performed in order to identify the molecular pathways and functions to which the predicted targets of the differentially expressed miRNAs belong. The database used by IPA to analyze miRNAs and their targets is Argonaute2 (http://www.ma.uni-heidelberg.de/apps/zmf/argonaute/). 𝑃<.01.

ID	Molecules in Network	𝑃-value	Focus Molecules	Top Functions
1	AKAP3, ATP2A2, C11ORF87, CNKSR2, CREB1, CUGBP2, EIF4E3, ELK1, FLRT2, HOXB2, HOXD12, IFNG, KLHDC10, KPNB1, MIR25, MIR150, MIR186, MIR221, MIR299, MIR143 (includes EG:406935), MIR182 (includes EG:406958), MIR200A, MIR200B, MIR200C, MIR34A, MYST4, OTOF, PAQR3, PER1, RPGRIP1L, SNRPA, SRCAP, UBFD1, USP6NL, WDR44	10E−24	11	Genetic Disorder, Skeletal and Muscular Disorders, Connective Tissue Disorders
2	ATP1B1, C4ORF16, CALU, DHX15, DIP2C, DNMT3A, DNMT3B, EVX2, FAM108C1, FBXL11, HOXA5, HOXA10, INO80, JPH3, KLHL18, MACF1, MAP2K6, MIR126, MIR100 (includes EG:406892), MIR130A (includes EG:406919), MIR130B (includes EG:406920), MIR132 (includes EG:406921), MIR148A (includes EG:406940), MIR20A, MIR29B, MIR29B1, MIR29B2, MIR29C, MPPED2 (includes EG:744), NUFIP2, SMARCE1, SOX6, ZFP36L2, ZNF238, ZNF318 (includes EG:24149)	10E–19	9	Genetic Disorder, Skeletal and Muscular Disorders, Infection Mechanism
3	ADIPOR2, AR, ARF4, CAND1, CCNT2, CDKN1A, CHSY1, FBXW7, FNDC3B, IRS1, JUN, KLF6, LASS2, MAP1D, MDM2, MIR93, MIR375, MIR1 (human), MIR106A (includes EG:406899), MIR106B (includes EG:406900), MIR145 (includes EG:406937), MIR183 (includes EG:406959), MIR196B, MIR99A, MTPN, NPAT, NPPC, PDCD4, PFTK1, PPM1D, SERP1, SERPINB5, SLC16A2, TDG, TRIM2	10E−18	9	Cancer, Reproductive System Disease, Cell Cycle
4	MIR376A, MIR376A1, MIR376A2	10E−2	1	Genetic Disorder, Skeletal and Muscular Disorders
5	MIR365, MIR365-1, MIR365-2	10E−2	1
6	EZH2, MIR101, MIR101-1, MIR101-2, MYCN	10E−2	1	Cancer, Cellular Movement, Reproductive System Disease