Computational Method for Estimating DNA Copy Numbers in Normal Samples, Cancer Cell Lines, and Solid Tumors Using Array Comparative Genomic Hybridization
Table 1
Median signal intensities calculated using parameters generated in this paper.
Cell line
Median signal
Comment
PC3
0.36
Homozygous deletion of PTEN
Data for 28 male cell lines provided by Affymetrix
1.14
Single copy of X chromosome outside of pseudoautosomal regions
NA04626
2.72
47,XXX
NA01416E
3.41
48,XXXX
NA06061
4.1
49,XXXXX
HTB27
5.31
CN estimated by qPCR for CCND1 is
CRL1620
5.79
CN estimated by qPCR for EGFR is
CCL251
6.41
CN estimated by qPCR for CCND1 is
HTB25
8.22
CN estimated by qPCR for CCND1 is
CRL2338
8.82
CN estimated by qPCR for CCND1 is
HTB27
9.42
CN estimated by qPCR for ERBB2 is
CRL1978
7.95
CN estimated by qPCR for CCND1 is
HTB23
11.26
CN estimated by qPCR for CCND1 is
HTB19
10.13
CN estimated by qPCR for EGFR is
HTB127
13.93
CN estimated by qPCR for CCND1 is
CRL2321
14.13
CN estimated by qPCR for CCND1 is
HTB41
13.25
CN estimated by qPCR for CCND1 is
HTB128
17.92
CN estimated by qPCR for CCND1 is
HTB127
21.34
CN estimated by qPCR for ERBB2 is
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