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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 389153, 24 pages
Review Article

Immunobiology of African Trypanosomes: Need of Alternative Interventions

Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Dr. Ottawa, ON, Canada K1A 0R6

Received 10 August 2009; Revised 29 October 2009; Accepted 23 December 2009

Academic Editor: Jorge Morales-Montor

Copyright © 2010 Toya Nath Baral. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Trypanosomiasis is one of the major parasitic diseases for which control is still far from reality. The vaccination approaches by using dominant surface proteins have not been successful, mainly due to antigenic variation of the parasite surface coat. On the other hand, the chemotherapeutic drugs in current use for the treatment of this disease are toxic and problems of resistance are increasing (see Kennedy (2004) and Legros et al. (2002)). Therefore, alternative approaches in both treatment and vaccination against trypanosomiasis are needed at this time. To be able to design and develop such alternatives, the biology of this parasite and the host response against the pathogen need to be studied. These two aspects of this disease with few examples of alternative approaches are discussed here.