Optimal Fluxes, Reaction Replaceability, and Response to Enzymopathies in the Human Red Blood Cell

Table 1

List of reactions considered in this work, including the corresponding number in the map of Figure 2, the abbreviation and the process. The 7 uptake fluxes, numbered 36 to 42, are as shown in Figure 2.

No.	Abbreviation	Chemical reaction
1	HK	GLU + ATP → G6P + ADP + H
2	PGI	G6P ↔ F6P
3	PFK	F6P + ATP → FDP + ADP + H
4	ALD	FDP ↔ GA3P + DHAP
5	TPI	DHAP ↔ GA3P
6	GAPDH	GA3P+NAD+P𝑖↔ 13DPG+NADH+H
7	PGK	13DPG + ADP ↔ 3PG + ATP
8	DPGM	13DPG → 23DPG + H
9	DPGase	23DPG + H2O → 3PG + P𝑖
10	PGM	3PG ↔ 2PG
11	EN	2PG ↔ PEP + H2O
12	PK	PEP + ADP + H → PYR + ATP
13	LDH	PYR + NADH + H ↔ LAC + NAD
14	G6PDH	G6P + NADP → 6PGL + NADPH + H
15	PGL	6PGL + H2O ↔ 6PGC + H
16	PDGH	6PGC + NADP → RL5P + NADPH + CO2
17	RPI	RL5P ↔ R5P
18	XPI	RL5P ↔ X5P
19	TKI	X5P + R5P ↔ S7P + GA3P
20	TA	GA3P + S7P ↔ E4P + F6P
21	TKII	X5P + E4P ↔ F6P + GA3P
22	PRPPsyn	R5P + ATP → PRPP + AMP
23	PRM	R1P ↔ R5P
24	HGPRT	PRPP + HX + H2O → IMP + 2P𝑖
25	AdPRT	PRPP + ADE + H2O → AMP + 2P𝑖
26	PNPase	INO + Pi ↔ HX + R1P
27	IMPase	IMP + H2O → INO + P𝑖 + H
28	AMPDA	AMP + H2O → IMP + NH3
29	AMPase	AMP + H2O → ADO + P𝑖 + H
30	ADA	ADO + H2O → INO + NH3
31	AK	ADO + ATP → ADP + AMP
32	ApK	2ADP ↔ ATP + AMP
33	ATPase	ATP → ADP + P𝑖
34	NADHase	NADH → NAD + H
35	NADPHase	NADPH → NADP + H