Exploring the 7p22.1 Chromosome as a Candidate Region for Autism
Physical mapping of the breakpoint on chromosome 7. (a) Dual color painting using directly FITC labelled (green) chromosome 7 paint and Rhodamine labelled (red) chromosome 16 paint. Both derivatives 7 and 16 (arrow) show clear evidence of a reciprocal exchange of chromatin from distal 7p and distal 16p, respectively. (b) Physical map of the genomic region 7p22.1 derived from the October 2009 version of the UCSC Genome Browser (http://genome.ucsc.edu/). The genomic clones covering the region flanking the translocation breakpoint are indicated by black lines (S: spanning, NT: non-translocated). The breakpoint (Bp) region is represented by an arrow. The genomic location of candidate genes is represented by rectangles.
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