Literature-Based Discovery of IFN-𝛾 and Vaccine-Mediated Gene Interaction Networks

Table 2

Gene annotation enrichment among top predicted genes in the generic IFNG and the IFNG-vaccine networks.

Category	Term	Count	P-Value	FDR
GOTERM_BP_ALL	GO:0050896~response to stimulus	43	2.99𝐸−22	5.71𝐸−19
GOTERM_BP_ALL	GO:0007154~cell communication	39	5.74𝐸−13	1.10𝐸−09
GOTERM_BP_ALL	GO:0007165~signal transduction	35	9.70𝐸−11	1.86𝐸−07
GOTERM_BP_ALL	GO:0006950~response to stress	29	7.14𝐸−20	1.37𝐸−16
GOTERM_BP_ALL	GO:0030154~cell differentiation	28	6.94𝐸−13	1.33𝐸−09
GOTERM_BP_ALL	GO:0006952~defense response	26	7.12𝐸−23	1.36𝐸−19
GOTERM_BP_ALL	GO:0006955~immune response	26	8.88𝐸−18	1.70𝐸−14
GOTERM_BP_ALL	GO:0008283~cell proliferation	23	9.37𝐸−16	1.70𝐸−12
GOTERM_BP_ALL	GO:0008219~cell death	23	2.28𝐸−15	4.46𝐸−12
GOTERM_BP_ALL	GO:0006915~apoptosis	22	9.38𝐸−15	1.78𝐸−11
GOTERM_BP_ALL	GO:0007242~intracellular signaling cascade	19	4.85𝐸−07	9.27𝐸−04
GOTERM_BP_ALL	GO:0001775~cell activation	18	5.86𝐸−19	1.12𝐸−15
GOTERM_BP_ALL	GO:0006954~inflammatory response	17	8.26𝐸−16	1.49𝐸−12
GOTERM_BP_ALL	GO:0046649~lymphocyte activation	14	1.77𝐸−14	3.38𝐸−11
GOTERM_BP_ALL	GO:0006468~protein amino acid phosphorylation	14	2.60𝐸−07	4.98𝐸−04
GOTERM_BP_ALL	GO:0006807~nitrogen compound metabolic process	13	4.47𝐸−08	8.56𝐸−05
GOTERM_BP_ALL	GO:0042110~T cell activation	12	9.02𝐸−14	1.73𝐸−10
GOTERM_BP_ALL	GO:0048534~hemopoietic or lymphoid organ development	12	4.57𝐸−11	8.74𝐸−08
GOTERM_CC_ALL	GO:0005576~extracellular region	29	5.33𝐸−18	8.27𝐸−15
GOTERM_MF_ALL	GO:0005125~cytokine activity	19	5.30𝐸−21	9.51𝐸−18
GOTERM_MF_ALL	GO:0008083~growth factor activity	12	6.77𝐸−12	1.21𝐸−08
KEGG_PATHWAY	hsa04060:Cytokine-cytokine receptor interaction	23	7.90𝐸−16	9.77𝐸−13
KEGG_PATHWAY	hsa04620:Toll-like receptor signaling pathway	13	3.12𝐸−10	3.91𝐸−07
KEGG_PATHWAY	hsa04660:T cell receptor signaling pathway	12	2.04𝐸−09	2.57𝐸−06
KEGG_PATHWAY	hsa04630:Jak-STAT signaling pathway	11	2.99𝐸−06	0.003745