Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44
Table 1
Frequency of MCTs, CD147, and CD44 expressions in tumour samples.
Tumour type
Expression
MCT1
MCT2
MCT4
CD147
CD44
Positive (%)
Positive (%)
Positive (%)
Positive (%)
Positive (%)
Cyta
PM
Cyta
PM
Cyta
PM
Cyta/PM
Cyta/PM
Breast carcinoma
22
21 (95.5)
5 (22.7)
24
34 (100.0)
0 (0.0)
24
19 (79.2)
1 (4.2)
28
13 (46.4)
27
8 (29.6)
Colon adenocarcinoma
32
23 (71.9)
19 (59.4)
29
29 (100.0)
0 (0.0)
26
19 (73.1)
0 (0.0)
34
13 (38.2)
31
4 (12.9)
Nonsmall cell lung cancer
23
14 (60.9)
5 (21.7)
21
21 (100.0)
0 (0.0)
23
16 (69.6)
0 (0.0)
28
13 (46.4)
27
12 (44.4)
Ovarian adenocarcinoma
24
18 (75.0)
10 (41.7)
30
18 (93.3)
0 (0.0)
28
13 (46.4)
1 (3.6)
26
11 (42.3)
28
2 (7.1)
Cyt: cytoplasm; PM: plasma membrane; awith or without plasma membrane staining. Note: for CD147 and CD44, frequency results are the same for cytoplasm and plasma membrane expression.