Figure 2: Main evasion mechanisms developed by Fasciola spp. against ADCC. Three main evasion mechanisms have been described: (i) production of superoxide dismutase and Glutathione S-transferase which neutralize superoxide radicals, (ii) cleavage of IgE and IgG involved in the ADCC, and (iii) production of blocking antibodies IgM and IgG2 which could inhibit eosinophil adhesion to flukes.