Insights into the Biology of IRES Elements through Riboproteomic Approaches

Table 1

RNA-binding proteins interacting with viral IRES.

ITAFS	Effect on IRES activity	IRES targets	Functions in RNA metabolism
PTB	Stimulation	FMDV, EMCV, TMEV, PV, HRV, HAV, HCV	Splicing, polyadenylation, RNA stability, localization
DRBP76:NF45	Repressor	HRV, HCV	Transcription, RNA transport, stability, viral replication
Ebp1/ PA2G4/ ITAF45	Stimulation	FMDV, EMCV∗	Transcription regulator
Unr	Stimulation	PV, HRV, HCV	Translation control
HSC70		FMDV, HCV	Viral replication
SRp20	Stimulation	PV	Splicing
PCBP2	Stimulation	PV, HRV, HAV, CVB3, FMDV∗,	RNA stability, translation control
		EMCV∗, HCV
Gemin5	Downregulation	FMDV, HCV	RNA-binding factor of SMN complex
hnRNP U		FMDV	RNA processing, stability, transcription
hnRNP K		FMDV	Transcription, RNA stability, translation control
DAZ1		FMDV	Translation control
G3BP		FMDV	Stress granules assembly
Gpiap1		FMDV, HCV	Transcription regulator, viral replication
Nucleolin	Stimulation	PV, HRV, FMDV, HCV	Ribosomal RNA maturation, transport
FBP2	Repressor	EV71	RNA stability
eIF2C/Ago		FMDV	Silencing
DHX9		HRV, FMDV, HCV	RNA helicase
DDX1		FMDV	RNA helicase
RACK1		HCV	Ribosomal subunits joining
IGF2BP1	Stimulation	HCV	RNA localization, stability, translation control
La	Stimulation	PV, EMCV, HAV#	Transcription, translation control
NSAP1/ hnRNP Q	Stimulation	HCV	RNA stability, translation control, SGs component
hnRNP L	Stimulation	HCV	RNA stability, translation control
hnRNP D	Stimulation	HCV	RNA stability, translation control
hnRNPA/B		EV71, HCV	RNA processing, translation control
GAPDH	Repressor	HAV	RNA transport, translation control
YB-BP1		HCV	Transcription, RNA stability, translation control

∗No effect, #suppression.