Pathogenesis of Insulin Resistance in Skeletal Muscle

Table 1

Defects in Glucose Metabolism in Insulin Resistant Conditions.

Insulin signaling	(1) Reduced insulin receptor tyrosine phosphorylation
	(2) Decreased IRS-1 tyrosine phosphorylation
	(3) Decreased PI3-kinase activation
Glucose transport	(1) Impaired GLUT4 translocation
	(2) Impaired GLUT 12 translocation
Glucose metabolism	(1) Decreased glucose phosphorylation
	(2) Decreased glucose oxidation and glycolytic FLUX
	(3) Impaired glycogen synthase