Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality
Photomicrographs of neuronal damage of the hypothalamus of a normothermic control (NC) (a), a sham-operated vehicle-treated heatstroke (SOH) mouse (b), a castrated, vehicle-treated heatstroke (CVH) mouse (c), and a castrated, testosterone-treated heatstroke (CTH) mouse (d). Two and half hours post-whole body heating, the hypothalamus of a SOH mouse or a CTH mouse showed cell shrinkage, pyknosis of the nucleus, and loss of Nissl substance. However, following castration, neuroprotection was induced (as shown in a CVH mouse) ×200.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.