BioMed Research International / 2010 / Article / Fig 4

Research Article

Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality

Figure 4

Photomicrographs of neuronal damage of the hypothalamus of a normothermic control (NC) (a), a sham-operated vehicle-treated heatstroke (SOH) mouse (b), a castrated, vehicle-treated heatstroke (CVH) mouse (c), and a castrated, testosterone-treated heatstroke (CTH) mouse (d). Two and half hours post-whole body heating, the hypothalamus of a SOH mouse or a CTH mouse showed cell shrinkage, pyknosis of the nucleus, and loss of Nissl substance. However, following castration, neuroprotection was induced (as shown in a CVH mouse) ×200.

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