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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 485306, 9 pages
Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality
1The Institute of Basic Medical Sciences, National Cheng Kung University School of Medicine, Tainan, Taiwan
2Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan
3Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
4Department of Obstetrics and Gynecology, Chi Mei Medical Center, Southern Taiwan University, Tainan, Taiwan
5Department of Biotechnology, Southern Taiwan University, Tainan, Taiwan
Received 1 December 2009; Accepted 3 February 2010
Academic Editor: Rene Anand
Copyright © 2010 Chian-Yuh Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. Bouchama and J. P. Knochel, “Heat stroke,” The New England Journal of Medicine, vol. 346, no. 25, pp. 1978–1988, 2002.
- J. P. Knochel and G. Reed, “Disorders of heat regulation,” in Clinical Disorders of Fluid and Electrolyte Mechanism, M. H. Maxwell, C. R. Kleeman, and R. G. Narins, Eds., pp. 1549–1590, McGraw-Hill, New York, NY, USA, 5th edition, 1994.
- T. F. O'Donnell Jr. and G. H. Clowes Jr., “The circulatory abnormalities of heat stroke,” The New England Journal of Medicine, vol. 287, no. 15, pp. 734–737, 1972.
- C.-K. Chang, C.-P. Chang, W.-T. Chiu, and M.-T. Lin, “Prevention and repair of circulatory shock and cerebral ischemia/injury by various agents in experimental heatstroke,” Current Medicinal Chemistry, vol. 13, no. 26, pp. 3145–3154, 2006.
- S. Chatterjee, S. Premachandran, D. Sharma, R.S. Bagewadikar, and T. B. Poduval, “Therapeutic treatment with L-arginine rescues mice from heat stroke-induced death: physiological and molecular mechanisms,” Shock, vol. 24, no. 4, pp. 341–347, 2005.
- K.-H. Shen, C.-H. Lin, H.-K. Chang, W.-C. Chen, and S.-H. Chen, “Premarin can act via estrogen receptors to rescue mice from heatstroke-induced lethality,” Shock, vol. 30, no. 6, pp. 668–674, 2008.
- J. Schröder, V. Kahlke, K.-H. Staubach, P. Zabel, and F. Stüber, “Gender differences in human sepsis,” Archives of Surgery, vol. 133, no. 11, pp. 1200–1205, 1998.
- M. K. Angele, M. G. Schwacha, A. Ayala, and I. H. Chaudry, “Effect of gender and sex hormones on immune responses following shock,” Shock, vol. 14, no. 2, pp. 81–90, 2000.
- A. Oberholzer, M. Keel, R. Zellweger, U. Steckholzer, O. Trentz, and W. Ertel, “Incidence of septic complications and multiple organ failure in severely injured patients is sex specific,” The Journal of Trauma, vol. 48, no. 5, pp. 932–937, 2000.
- D. E. Remmers, W. G. Cioffi, K. I. Bland, P. Wang, M. K. Angele, and I. H. Chaudry, “Testosterone: the crucial hormone responsible for depressing myocardial function in males after trauma-hemorrhage,” Annals of Surgery, vol. 227, no. 6, pp. 790–799, 1998.
- M. W. Wichmann, R. Zellweger, C. M. DeMaso, A. Ayala, and I. H. Chaudry, “Mechanism of immunosuppression in males following trauma-hemorrhage: critical role of testosterone,” Archives of Surgery, vol. 131, no. 11, pp. 1186–1192, 1996.
- M. W. Wichmann, M. K. Angele, A. Ayala, W. G. Cioffi, and I. H. Chaudry, “Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock,” Shock, vol. 8, no. 4, pp. 242–248, 1997.
- D. E. Remmers, P. Wang, W. G. Cioffi, K. I. Bland, and I. H. Chaudry, “Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males,” American Journal of Physiology, vol. 273, no. 6, pp. H2919–H2925, 1997.
- N. Shvareva, J. Kaplanski, L. Abramovich, and U. A. Sod-Moriah, “Testosterone modifies response to chronic heat exposure in rats,” Comparative Biochemistry and Physiology Part A, vol. 120, no. 4, pp. 575–578, 1998.
- H. Grogan and P. M. Hopkins, “Heat stroke: implications for critical care and anaesthesia,” British Journal of Anaesthesia, vol. 88, no. 5, pp. 700–707, 2002.
- K.-C. Lu, J.-Y. Wang, S.-H. Lin, P. Chu, and Y.-F. Lin, “Role of circulating cytokines and chemokines in exertional heatstroke,” Critical Care Medicine, vol. 32, no. 2, pp. 399–403, 2004.
- W. A. Pulsinelli, J. B. Brierley, and F. Plum, “Temporal profile of neuronal damage in a model of transient forebrain ischemia,” Annals of Neurology, vol. 11, no. 5, pp. 491–498, 1982.
- S.-H. Chen, F.-M. Chang, K.-C. Niu, M. Y.-S. Lin, and M.-T. Lin, “Resuscitation from experimental heatstroke by estrogen therapy,” Critical Care Medicine, vol. 34, no. 4, pp. 1113–1118, 2006.
- M. K. Angele, M. C. Frantz, and I. H. Chaudry, “Gender and sex hormones influence the response to trauma and sepsis—potential therapeutic approaches,” Clinics, vol. 61, no. 5, pp. 479–488, 2006.
- B. Bilińska, B. Wiszniewska, K. Kosiniak-Kamysz, et al., “Hormonal status of male reproductive system: androgens and estrogens in the testis and epididymis. In vivo and in vitro approaches,” Reproductive Biology, vol. 6, supplement 1, pp. 43–58, 2006.
- M. K. Angele, M. W. Knöferl, M. G. Schwacha, et al., “Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage,” American Journal of Physiology, vol. 277, no. 1, pp. C35–C42, 1999.
- A. Ayala, M. M. Perrin, W. Ertel, and I. H. Chaudry, “Differential effects of hemorrhage on Kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release,” Cytokine, vol. 4, no. 1, pp. 66–75, 1992.
- M. Johnson, E. Ramey, and P. W. Ramwell, “Androgen mediated sensitivity in platelet aggregation,” American Journal of Physiology, vol. 232, no. 4, pp. H381–385, 1977.
- A. Uzunova, E. Ramey, and P. W. Ramwell, “Effect of testosterone, sex and age on experimentally induced arterial thrombosis,” Nature, vol. 261, no. 5562, pp. 712–713, 1976.
- A. A. L. Ajayi, R. Mathur, and P. V. Halushka, “Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses,” Circulation, vol. 91, no. 11, pp. 2742–2747, 1995.
- K. Matsuda, A. Ruff, T. A. Morinelli, R. S. Mathur, and P. V. Halushka, “Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets,” American Journal of Physiology, vol. 267, no. 3, pp. H887–H893, 1994.